When Neurotic, struggling songwriter, Catherine Brown's life in New York City falls apart, she is forced to confront her past when she spends the summer at her childhood home in Woodstock, New York, learning that becoming successful means becoming your true self first.

After a mysterious, lost night on their honeymoon, a newlywed couple finds themselves dealing with an earlier-than-planned pregnancy. While recording everything for posterity, the husband begins to notice odd behavior in his wife that they initially write off to nerves, but, as the months pass, it becomes evident that the dark changes to her body and mind have a much more sinister origin.

In 1970, the four hundred year-old skilled samurai Saya is sent to the Kanto High School in an American military base in Tokyo by the Council, a secret society that has been hunting vampires for centuries. Saya has the appearance of a teenager but is the tormented half-breed creature with the soul of her human father and the powers and need of blood of her vampire mother. She is obsessed to face the powerful demon Onigen that killed her father. In the base, Saya saves Alice McKee, who is the daughter of General McKee and commander of the base, from the attack of several vampires. When General McKee is killed by a member of the Council, Alice runs to the hotel where Saya is lodged. They join forces and go to the countryside to chase Onigen.

At 17 Mike O'Donnell is on top of the world: he's the star of his high school basketball team, is a shoo-in for a college scholarship, and is dating his soul-mate, Scarlet. But at what's supposed to be his big game where a college scout is checking him out, Scarlet reveals that she's pregnant. Mike decides to leave the game and asks Scarlet to marry him, which she does. During their marriage, Mike can only whine about the life he lost because he married her, so she throws him out. When he also loses his job, he returns to the only place he's happy at, his old high school. While looking at his high school photo, a janitor asks him if he wishes he could be 17 again and he says yes. One night while driving he sees the janitor on a bridge ready to jump, and goes after him. When he returns to his friend Ned's house, where he has been staying, he sees that he is 17 again. He decides to take this opportunity to get the life he lost.